مقاله 2012: ژنوم قارچ گنودرما

Plant genetics: The Lingzhi mushroom genome

A team of international researchers led by Shilin Chen and Chao Sun at the Chinese Academy of Medical Sciences and Peking Union Medical College¹ have now sequenced the genome of Lingzhi mushroom using the latest sequencing technology and optical mapping approaches. They found that the Lingzhi mushroom genome contains a large assortment of genes and gene clusters, many of which are involved in the production of secondary metabolites.

In particular, the researchers found 78 genes that have important roles in the biosynthesis of triterpenoids — a highly diverse group of steroids with therapeutic properties. By studying the Lingzhi genome, they hope to uncover alternative methods allowing the manufacture of triterpenoids on a large scale.

The authors of this work are from:
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA; Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics, UW Biotechnology Center, University of Wisconsin–Madison, Madison, Wisconsin, USA; Architecture et Fonction des Macromolécules Biologiques, Aix-Marseille University, Marseille, France; de Biotechnologie des Champignons Filamenteux, Aix-Marseille University, Marseille, France; National Evolutionary Synthesis Center, Durham, North Carolina, USA; China Academy of Chinese Medical Sciences, Beijing, China.

Reference

1. Chen, S. et al. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nature Commun. 3, 913 (2012).
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