مقاله ۲۰۱۳ (امروز) توالی یابی ژنوم قارچ دکمه ای

 Agaricus bisporus genome sequence: A commentary

• Richard W. Kerrigan^a, ,
• Michael P. Challen^b, ,
• Kerry S. Burton^{c, ,}

^{چکیده  در ادامه مطلب}

^{متن کامل ایمیل بزنید}

• ^a Sylvan Biosciences, 198 Nolte Drive, Kittanning, PA 16201, United States
• ^b Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
• ^c East Malling Research, New Road, East Malling, Kent ME19 6BJ, UK

• http://dx.doi.org.ezproxy2.apus.edu/10.1016/j.fgb.2013.03.002, How to Cite or Link Using DOI

• Permissions & Reprints

Highlights

Abstract

The genomes of two isolates of Agaricus bisporus have been sequenced recently. This soil-inhabiting fungus has a wide geographical distribution in nature and it is also cultivated in an industrialized indoor process ($4.7 bn annual worldwide value) to produce edible mushrooms. Previously this lignocellulosic fungus has resisted precise econutritional classification, i.e. into white- or brown-rot decomposers. The generation of the genome sequence and transcriptomic analyses has revealed a new classification, ‘humicolous’, for species adapted to grow in humic-rich, partially decomposed leaf material. The Agaricus biporus genomes contain a collection of polysaccharide and lignin-degrading genes and more interestingly an expanded number of genes (relative to other lignocellulosic fungi) that enhance degradation of lignin derivatives, i.e. heme-thiolate peroxidases and β-etherases. A motif that is hypothesized to be a promoter element in the humicolous adaptation suite is present in a large number of genes specifically up-regulated when the mycelium is grown on humic-rich substrate. The genome sequence of A. bisporus offers a platform to explore fungal biology in carbon-rich soil environment and terrestrial cycling of carbon, nitrogen, phosphorus and potassium.

Keywords

• Agaricus bisporus;
• Cultivated mushroom;
• Genome adaptation;
• Physiological specialization;
• Carbon cycling;
• Bioremediation