مقاله 2012: ژنوم قارچ گنودرما

Plant genetics: The Lingzhi mushroom genome

A team of international researchers led by Shilin Chen and Chao Sun at the Chinese Academy of Medical Sciences and Peking Union Medical College¹ have now sequenced the genome of Lingzhi mushroom using the latest sequencing technology and optical mapping approaches. They found that the Lingzhi mushroom genome contains a large assortment of genes and gene clusters, many of which are involved in the production of secondary metabolites.

In particular, the researchers found 78 genes that have important roles in the biosynthesis of triterpenoids — a highly diverse group of steroids with therapeutic properties. By studying the Lingzhi genome, they hope to uncover alternative methods allowing the manufacture of triterpenoids on a large scale.

The authors of this work are from:
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA; Laboratory for Molecular and Computational Genomics, Department of Chemistry, Laboratory of Genetics, UW Biotechnology Center, University of Wisconsin–Madison, Madison, Wisconsin, USA; Architecture et Fonction des Macromolécules Biologiques, Aix-Marseille University, Marseille, France; de Biotechnologie des Champignons Filamenteux, Aix-Marseille University, Marseille, France; National Evolutionary Synthesis Center, Durham, North Carolina, USA; China Academy of Chinese Medical Sciences, Beijing, China.

Reference

1. Chen, S. et al. Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nature Commun. 3, 913 (2012).
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Effect of Dongchunghacho (Cordyceps militaris) on hyperglycemia and dyslipidemia in type 2 diabetic db/db mice

Abstract

آنزیم های تجزیه کننده چوب در قارچ پوسیدگی سفید  Trametes trogii

Copper induction of lignin-modifying enzymes in the white-rot fungus Trametes trogii

فاکوگالاکتان قارچ دکمه ای: خصوصیات ساختاری و استفاده های دارویی

Agaricus bisporus fucogalactan: Structural characterization and pharmacological approaches

The fucogalactan from A. bisporus (EFP-Ab) obtained on aqueous extraction followed by purification had M_w 37.1x10⁴ g.mol⁻¹ relative to a (1→6)-linked α-D-Galp main-chain partially methylated at HO-3, and partially substituted at O-2 by nonreducing end-units of α-L-Fucp or β-D-Galp. EFP-Ab also inhibited significantly the neurogenic and inflammatory phases of formalin-induced licking, however, the antinociceptive effect was more pronounced against the inflammatory phase with ID₅₀ of 36.0 (25.8–50.3) mg.kg⁻¹. In addition, EFP-Ab decreased the lethality induced by CLP. Its administration reduced the late mortality rate by 40%, prevented neutrophil accumulation in lungs and markedly decreased iNOS and COX-2 protein expression by ileum cells. These data show for the first time that EFP-Ab has significant anti-sepsis, antinociceptive and anti-inflammatory actions, which seems to be related to the decreased iNOS and COX-2 expression. Collectively, the present results demonstrate that EFP-Ab could constitute an attractive molecule of interest for the development of new drugs.

مطالعه ای بر روی خصوصیات درمانی گنودرما لوسیدیوم Ganoderma lucidum

Modulation of Lipoprotein Cholesterol Levels in Plasmodium berghei Malarial Infection by Crude Aqueous Extract of Ganoderma lucidum

In this study, attempt is made to establish changes in serum and liver lipoprotein cholesterols accompanying Plasmodium berghei malarial infection in mice treated with aqueous extract of Ganoderma lucidum at 100, 250, and 500 mg/kg body weight in comparison with 15 mg/kg chloroquine (CQ). Significant increases in all the lipoprotein fractions were observed in infected untreated mice compared with normal control mice. Treatment with 100 and 250 mg/kg G. lucidum extract produced significant reduction in serum total cholesterol (TC) and low-density cholesterol (LDL-C) contents compared with 500 mg/kg G. lucidum and CQ. Treatment with CQ, however, produced significant reduction in hepatic TC and LDL-C compared with the extract. A dose-dependent significant increase in serum high-density lipoprotein cholesterol (HDL-C) was observed in the G. lucidum treated mice compared with normal control but significantly lower compared with CQ-treated mice. Liver HDL-C level was significantly higher in CQ-treated mice compared with normal control and significantly lower compared with G. lucidum-treated and infected untreated mice. A dose-dependent effect of the extract was observed in both serum and liver very-low density lipoprotein cholesterol (VLDL-C). The implication of these results is discussed with respect to the parasite survival and proliferation in the serum and liver.